An Initiative of the European Commission, facilitated by the EDITH CSA and VPH institute, the Virtual Human Twins (VHT) aim to foster and accelerate the development of integrated, validated digital representations of the human body. These VHTs hold substantial potential for medical research and healthcare delivery, contributing to a deeper understanding of human physiology, pathology, and disease aetiology, as well as facilitating personalised, patient-centric medicine. This Initiative includes the envisaged European VHT platform, enabling the pooling of resources, assets to further develop the science and technology required for building advanced VHT-based solutions in health and care.